HIGH FAT DIET INCREASES THE SEVERITY OF COLLAGEN-INDUCED ARTHRITIS IN MICE BY ALTERING THE GUT MICROBIAL COMMUNITY

High fat diet increases the severity of collagen-induced arthritis in mice by altering the gut microbial community

Abstract Objectives Research has demonstrated that obesity may be associated with rheumatoid arthritis (RA).In addition, gut microbiota and its metabolites contribute to the occurrence and development of RA and obesity.However, the mechanism by which obesity affects RA remains unclear.In this study, we aimed to investigate whether gut microbiota an

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Ginseng-Angelica-Sansheng-Pulvis Boosts Neurogenesis Against Focal Cerebral Ischemia-Induced Neurological Deficiency

BackgroundThe traditional Chinese medicine Ginseng-Angelica-Shanseng-Pulvis (GASP) has Chaise Lounge been used to treat stroke for 300 years.This present study investigated if it can induce increases in neurogenesis following cerebral ischemic injury.MethodsRats following middle cerebral artery occlusion were orally treated with high, medium, and l

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Modelling the Vehicle Routing Problem with Delivery and Pickup in E-Commerce Forward-Reverse Logistics Networks Based on the Triple Bottom Line Framework

With the recent surge of industrialisation and advancement of technologies, supply chain management has been widely permeated by the practice of reverse logistics and zero-waste circular economy.Literature on these topics has covered several reverse logistics optimisation problems; however, the area of the vehicle routing Sticker problem has only b

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